Phenotypes Associated with This Genotype

Genotype
MGI:3840095

• Allelic Composition: Nup155^{Gt(RRD107)Byg}/Nup155⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:147210 )

N • no overt structural abnormalities in heart and skeletal muscle are seen

N • no overt differences in the morphology of cardiomyocytes and the atrial tissue architecture are seen

atrial fibrillation ( J:147210 )

• mice develop atrial fibrillation unlike wild-type mice

abnormal impulse conducting system conduction ( J:147210 )

absent P wave ( J:147210 )

• mice lack discrete P waves

abnormal RR interval ( J:147210 )

• mice exhibit irregular R-R intervals unlike in wild-type mice

nervous system

abnormal action potential ( J:147210 )

• atrial myocytes exhibit shortened action potential duration compared to in wild-type mice