Analysis Tools
cellular
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• LPS-treated mice exhibit cortical necrosis unlike similarly treated wild-type mice
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immune system
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• in the kidney and liver 6 hours after LPS-exposure unlike similarly treated wild-type mice
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• 6 hours after LPS-exposure, mice exhibit a 2- to 3- fold increase in circulating neutrophils that is sustained and more pronounced than in similarly treated wild-type mice
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• following activation with phorbol myristate acetate (PMA) or PMA and N-formyl-Met-Leu-Phe, neutrophils exhibit a 100% increase in respiratory burst compared to similarly treated wild-type mice
• neutrophils are more easily primed and activated compared to wild-type cells
• neutrophils exhibit spontaneous activation unlike wild-type cells
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• mice exposed to LPS develop septic shock lasting at least 4 days accompanied by weight loss and intestinal edema before onset of recovery unlike similarly treated wild-type mice that recover within 24 hours of exposure
• unlike in wild-type mice, LPS exposure leads to extensive damage in multiple organs including the ileum, kidney, and liver
• however, removal of neutrophils using cyclophosphamide treatment restores normal response to LPS
• LPS-exposed mice exhibit increased plasma lactate dehydrogenase, aspartate and alanine aminotransferase, and blood nitrogen urea compared to similarly treated wild-type mice
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• mice exposed to LPS develop septic shock lasting at least 4 days before recovery unlike similarly treated wild-type mice
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homeostasis/metabolism
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• following LPS exposure
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• following LPS exposure
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• following LPS exposure
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• following LPS exposure
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• higher plasma LDH levels following LPS exposure
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renal/urinary system
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• LPS-treated mice exhibit cortical necrosis unlike similarly treated wild-type mice
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• LPS-treated mice exhibit glomerular collapse as early as 6 hours post-exposure unlike similarly treated wild-type mice
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• LPS-treated mice exhibit extensive vacuolization of proximal convoluted tubules unlike similarly treated wild-type mice
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liver/biliary system
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• 72 hours after LPS-exposure, mice exhibit fatty vacuolization in the liver parenchyma unlike similarly treated wild-type mice
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digestive/alimentary system
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• unlike in wild-type mice, LPS-treated mice exhibit the presence of debris and mucus plugs in the intestinal lumen and in between microvilli indicating necrosis of mucosal epithelial cells at 24 hours post-exposure
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• following LPS exposure
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growth/size/body
weight loss
(
J:23804
)
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• following LPS exposure
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hematopoietic system
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• 72 hours after LPS-exposure, hematopoiesis shifts to granulopoiesis unlike in similarly treated wild-type mice
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• in the kidney and liver 6 hours after LPS-exposure unlike similarly treated wild-type mice
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• 6 hours after LPS-exposure, mice exhibit a 2- to 3- fold increase in circulating neutrophils that is sustained and more pronounced than in similarly treated wild-type mice
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• following activation with phorbol myristate acetate (PMA) or PMA and N-formyl-Met-Leu-Phe, neutrophils exhibit a 100% increase in respiratory burst compared to similarly treated wild-type mice
• neutrophils are more easily primed and activated compared to wild-type cells
• neutrophils exhibit spontaneous activation unlike wild-type cells
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