Phenotypes Associated with This Genotype

Genotype
MGI:3839951

• Allelic Composition: Mre11a^tm1Dof/Mre11a^tm1Dof
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:147247 )

• although present at E9.5, no mice are recovered at E10.5

embryo

abnormal embryo development ( J:147247 )

• at E9.5 and E7.5, embryos are disorganized with a poorly defined axis unlike in wild-type mice

embryonic growth arrest ( J:147247 )

• at E9.5 and E7.5

cardiovascular system

abnormal heart development ( J:147247 )

• at E9.5, mice exhibit no gross evidence of heart development unlike wild-type mice