Phenotypes Associated with This Genotype

Genotype
MGI:3839910

• Allelic Composition: Tg(MMTV-CCND1)1Esmp/0; Tg(MMTV-Cdc37)1Stp/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

integument

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated