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Phenotypes Associated with This Genotype
Genotype
MGI:3839909
Allelic
Composition
Tg(MMTV-Cdc37)1Stp/0
Tg(MMTV-Myc)141-3Led/0
Genetic
Background
involves: C57BL/6 * CD-1 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Cdc37)1Stp mutation (1 available)
Tg(MMTV-Myc)141-3Led mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 50% of female mice develop tumors by 115 days compared to the same rate at 250 days in Tg(MMTV-Myc)141-3Led mice
• females exhibit increased tumors per mouse compared to in Tg(MMTV-Myc)141-3Led mice
• virgin females develop a wider spectrum of fast growing tumors compared to Tg(MMTV-Myc)141-3Led virgin females
• breeding females develop mammary ductal and alveolar adenocarcinomas
• Leydig cell tumors in males as young as 10 months
• in virgin females

reproductive system
• 75% of male mice exhibit Leydig cell hyperplasia at 400 days
• Leydig cell tumors in males as young as 10 months

endocrine/exocrine glands
• breeding females develop mammary ductal and alveolar adenocarcinomas
• 75% of male mice exhibit Leydig cell hyperplasia at 400 days
• Leydig cell tumors in males as young as 10 months

integument
• breeding females develop mammary ductal and alveolar adenocarcinomas

digestive/alimentary system

craniofacial

growth/size/body


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory