Phenotypes Associated with This Genotype

Genotype
MGI:3839908

• Allelic Composition: Tg(MMTV-Cdc37)2Stp/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:62465 )

♀ • by 17 months of age, 45% of female mice develop mammary or lymphoid tumors

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • in 20% of female mice

increased lymphoma incidence ( J:62465 )

♀ • in 20% of female mice

increased sarcoma incidence ( J:62465 )

♀ • in 5% of female mice

endocrine/exocrine glands

abnormal mammary gland development ( J:62465 )

♂ • 30% to 40% of male mice exhibit development of the mammary ductal system by 7 months of age

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • in 20% of female mice

integument

abnormal mammary gland development ( J:62465 )

♂ • 30% to 40% of male mice exhibit development of the mammary ductal system by 7 months of age

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • in 20% of female mice