Phenotypes Associated with This Genotype

Genotype
MGI:3839907

• Allelic Composition: Tg(MMTV-Cdc37)1Stp/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:62465 )

♀ • by 22 months of age, 100% of female mice develop mammary or lymphoid tumors

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma

increased lymphoma incidence ( J:62465 )

♀ • in 50% of female mice

endocrine/exocrine glands

abnormal mammary gland development ( J:62465 )

♂ • 60% to 70% of male mice exhibit development of the mammary ductal system by 7 months of age

♂ • during the first 6 weeks after birth, most male mice fail to exhibit regression of initial breast sprouts observed in wild-type mice

♂ • by 8 weeks, 70% of male mice have well-developed branching duct systems unlike in wild-type male mice

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma

integument

abnormal mammary gland development ( J:62465 )

♂ • 60% to 70% of male mice exhibit development of the mammary ductal system by 7 months of age

♂ • during the first 6 weeks after birth, most male mice fail to exhibit regression of initial breast sprouts observed in wild-type mice

♂ • by 8 weeks, 70% of male mice have well-developed branching duct systems unlike in wild-type male mice

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma