Phenotypes Associated with This Genotype

Genotype
MGI:3839901

• Allelic Composition: Tg(MMTV-CCND1)1Esmp/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:70571 )

• 4 of 9 mice develop multiple independent tumors

increased mammary gland tumor incidence ( J:70571 )

• in 5 of 9 mice with mean onset at 551 days

increased mammary adenocarcinoma incidence ( J:70571 )

• with papillary and cribriform elements

increased mammary adenoacanthoma incidence ( J:70571 )

increased testis tumor incidence ( J:70571 )

♂ • some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall

increased sarcoma incidence ( J:70571 )

• some mice develop metastatic spindle cell sarcoma of the uterine wall

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:70571 )

• in 5 of 9 mice with mean onset at 551 days

increased mammary adenocarcinoma incidence ( J:70571 )

• with papillary and cribriform elements

increased mammary adenoacanthoma incidence ( J:70571 )

increased testis tumor incidence ( J:70571 )

♂ • some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall

integument

increased mammary gland tumor incidence ( J:70571 )

• in 5 of 9 mice with mean onset at 551 days

increased mammary adenocarcinoma incidence ( J:70571 )

• with papillary and cribriform elements

increased mammary adenoacanthoma incidence ( J:70571 )

reproductive system

increased testis tumor incidence ( J:70571 )

♂ • some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall