Phenotypes Associated with This Genotype

Genotype
MGI:3839869

• Allelic Composition: Trim72^tm1Hta/Trim72^tm1Hta
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:146965 )

• progressive muscle pathologies develop with age

decreased skeletal muscle fiber diameter ( J:146965 )

• at 10-11 months of age

centrally nucleated skeletal muscle fibers ( J:146965 )

• increased number of central nuclei in mice 10-11 months of age

abnormal muscle physiology ( J:146965 )

impaired skeletal muscle contractility ( J:146965 )

• limited defects in younger mice after membrane injury

• contractile function severely compromised in older mice

abnormal muscle regeneration ( J:146965 )

• reduced ability to repair muscle fiber membrane damage

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:146965 )

• repeated cycles of down hill running leads to declining performance

• cannot sustain a running rate of 20m/min