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Phenotypes Associated with This Genotype
Genotype
MGI:3839791
Allelic
Composition
Men1tm1Gfk/Men1tm1Gfk
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Gfk mutation (1 available); any Men1 mutation (17 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

neoplasm
• 7 of 21 mice develop pancreatic islet tumors that are positive for insulin
• islet tumors develop earlier and are more severe than those observed in Men1 knock-out heterozygotes
• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

endocrine/exocrine glands
• prominent in multiple islets consisting of beta cell hyperplasia
• 7 of 21 mice develop pancreatic islet tumors that are positive for insulin
• islet tumors develop earlier and are more severe than those observed in Men1 knock-out heterozygotes
• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple endocrine neoplasia type 1 DOID:10017 OMIM:131100
J:89898


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory