Phenotypes Associated with This Genotype

Genotype
MGI:3839787

• Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:118516 )

• 25% compared to in wild-type mice

increased white fat cell number ( J:118516 )

• the number of adipocytes in the parametrial fat pad is increased 1.9-fold compared to in wild-type mice

• adipocyte hyperplasia is observed in small, medium, and large adipocytes

• the number of small adipocytes is increased 3-fold compared to in wild-type mice

increased inguinal fat pad weight ( J:118516 )

increased parametrial fat pad weight ( J:118516 )

• 80% at 130 days compared to in wild-type mice

respiratory system

increased lung adenocarcinoma incidence ( J:120835 )

• 8% of mice develop lung adenomas as solitary, uniform nodules with clear borders and homogeneous tumor cell type

neoplasm

increased ovary tumor incidence ( J:236161 )

• mice occasionally develop ovarian epithelial tumors

increased lung adenocarcinoma incidence ( J:120835 )

• 8% of mice develop lung adenomas as solitary, uniform nodules with clear borders and homogeneous tumor cell type

skeleton

abnormal tooth morphology ( J:102001 )

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type mice

growth/size/body

abnormal tooth morphology ( J:102001 )

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type mice

increased body weight ( J:118516 )

• at 60 to 120 days

increased kidney weight ( J:118516 )

• 37% compared to in wild-type mice

homeostasis/metabolism

decreased circulating testosterone level ( J:115443 )

increased circulating cholesterol level ( J:118516 )

abnormal response/metabolism to endogenous compounds ( J:115443 )

• testosterone treatment increases the seminal vesicle weight more than in similarly treated wild-type mice

nervous system

increased brain weight ( J:118516 )

renal/urinary system

increased kidney weight ( J:118516 )

• 37% compared to in wild-type mice

craniofacial

abnormal tooth morphology ( J:102001 )

• the total area of connective tissue islands in the junctional epithelium is larger than in wild-type mice

endocrine/exocrine glands

abnormal prostate gland dorsolateral lobe morphology ( J:115443 )

♂ • DNA content is increased 47% compared to in wild-type mice

increased ovary tumor incidence ( J:236161 )

• mice occasionally develop ovarian epithelial tumors

abnormal prostate gland physiology ( J:115443 )

♂ • ventral prostate and dorsolateral prostate epithelial proliferation is increased 2- and 3.8-fold, respectively, compared to in wild-type mice

♂ • luminal epithelial apoptosis is increased 8.7-fold compared to in wild-type mice

♂ • testosterone treatment does not alter increased luminal epithelial apoptosis rates

reproductive system

abnormal prostate gland dorsolateral lobe morphology ( J:115443 )

♂ • DNA content is increased 47% compared to in wild-type mice

increased ovary tumor incidence ( J:236161 )

• mice occasionally develop ovarian epithelial tumors

abnormal prostate gland physiology ( J:115443 )

♂ • ventral prostate and dorsolateral prostate epithelial proliferation is increased 2- and 3.8-fold, respectively, compared to in wild-type mice

♂ • luminal epithelial apoptosis is increased 8.7-fold compared to in wild-type mice

♂ • testosterone treatment does not alter increased luminal epithelial apoptosis rates