Phenotypes Associated with This Genotype

Genotype
MGI:3839773

• Allelic Composition: Men1^tm1.1Ctre/Men1⁺; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:133299 )

• median lifespan is 402 days compared to 546 days for Men1^tm1.1Ctre heterozygotes

neoplasm

increased adrenal gland tumor incidence ( J:133299 )

• adrenal cortical tumor (10% of mice)

increased pheochromocytoma incidence ( J:133299 )

• in 45% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

increased parathyroid gland tumor incidence ( J:133299 )

• 50% of mice exhibit parathyroid gland tumors

increased thyroid C-cell carcinoma incidence ( J:133299 )

• mice exhibit thyroid C-cell carcinomas (96%)

increased pancreas tumor incidence ( J:133299 )

• 55% of mice exhibit pancreatic islet tumors

increased metastatic potential ( J:133299 )

• metastasis in the lungs (70% of mice)

nervous system

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:133299 )

• adrenal cortical tumor (10% of mice)

increased pheochromocytoma incidence ( J:133299 )

• in 45% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

increased parathyroid gland tumor incidence ( J:133299 )

• 50% of mice exhibit parathyroid gland tumors

increased thyroid C-cell carcinoma incidence ( J:133299 )

• mice exhibit thyroid C-cell carcinomas (96%)

increased pancreas tumor incidence ( J:133299 )

• 55% of mice exhibit pancreatic islet tumors