Phenotypes Associated with This Genotype

Genotype
MGI:3839771

• Allelic Composition: Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:133299 )

• median lifespan is 372 days compared to 546 days for Men1^tm1.1Ctre heterozygotes

neoplasm

increased pheochromocytoma incidence ( J:133299 )

• in 40% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit tumors of the pituitary anterior lobe (42%)

• however, no parathyroid adenomas are observed

increased pituitary melanotroph tumor incidence ( J:133299 )

• all mice exhibit tumors of the pituitary intermediate lobe

increased thyroid C-cell carcinoma incidence ( J:133299 )

• all mice exhibit metastic thyroid C-cell carcinomas

increased metastatic potential ( J:133299 )

• 60% of mice exhibit lung metastasis

increased lung tumor incidence ( J:133299 )

• in 60% of mice

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:133299 )

• in 40% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit tumors of the pituitary anterior lobe (42%)

• however, no parathyroid adenomas are observed

increased pituitary melanotroph tumor incidence ( J:133299 )

• all mice exhibit tumors of the pituitary intermediate lobe

increased thyroid C-cell carcinoma incidence ( J:133299 )

• all mice exhibit metastic thyroid C-cell carcinomas

respiratory system

increased lung tumor incidence ( J:133299 )

• in 60% of mice

nervous system

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit tumors of the pituitary anterior lobe (42%)

• however, no parathyroid adenomas are observed

increased pituitary melanotroph tumor incidence ( J:133299 )

• all mice exhibit tumors of the pituitary intermediate lobe