Phenotypes Associated with This Genotype

Genotype
MGI:3839765

• Allelic Composition: Men1^tm1Ctre/Men1⁺
• Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased stomach tumor incidence ( J:67128 )

• one mouse developed a gastric neuroendocrine tumor

increased adrenal gland tumor incidence ( J:67128 )

• 20% of mice develop adrenal cortical carcinomas

increased pheochromocytoma incidence ( J:67128 )

• in 7% of mice

increased pituitary adenoma incidence ( J:67128 )

• pituitary adenomas develop in 26% of mice by 16 months of age

• all pituitary tumors secrete prolactin but not ACTH

increased prolactinoma incidence ( J:67128 )

increased parathyroid adenoma incidence ( J:67128 )

• as early as 9 months, 24% of mice develop parathyroid adenomas compared to 2% of wild-type mice

increased thyroid adenoma incidence ( J:67128 )

• follicular adenoma

increased pancreas tumor incidence ( J:67128 )

• pancreatic islet cell tumors develop in 4 of 10 mice at 9 months of age unlike in wild-type mice

• by 16 months of age mice develop more numerous, large tumors

• at 22 months, one mouse exhibited capsular invasion

• by 22 months of age, 28% of mice exhibit pancreatic islet tumors unlike in wild-type mice

• pancreatic tumors begin at a slightly later age than in Men1^tm1.1Ctre heterozygotes

increased carcinoma incidence ( J:67128 )

• 20% of mice develop adrenal cortical carcinomas

increased lung adenocarcinoma incidence ( J:67128 )

• in 22% of mice

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:67128 )

• 20% of mice develop adrenal cortical carcinomas

increased pheochromocytoma incidence ( J:67128 )

• in 7% of mice

increased pituitary adenoma incidence ( J:67128 )

• pituitary adenomas develop in 26% of mice by 16 months of age

• all pituitary tumors secrete prolactin but not ACTH

increased prolactinoma incidence ( J:67128 )

increased parathyroid adenoma incidence ( J:67128 )

• as early as 9 months, 24% of mice develop parathyroid adenomas compared to 2% of wild-type mice

increased thyroid adenoma incidence ( J:67128 )

• follicular adenoma

thyroid gland cyst ( J:67128 )

• thyroid cysts

abnormal pancreas morphology ( J:67128 )

• some mice exhibit fatty replacement unlike wild-type mice

abnormal pancreatic acinar cell morphology ( J:67128 )

• some mice exhibit duct inflammation, acinar cysts, focal acinar dysplasia, and focal acinar necrosis unlike wild-type mice

pancreatic islet hyperplasia ( J:67128 )

• in 4 of 10 mice at 9 months of age

increased pancreas tumor incidence ( J:67128 )

• pancreatic islet cell tumors develop in 4 of 10 mice at 9 months of age unlike in wild-type mice

• by 16 months of age mice develop more numerous, large tumors

• at 22 months, one mouse exhibited capsular invasion

• by 22 months of age, 28% of mice exhibit pancreatic islet tumors unlike in wild-type mice

• pancreatic tumors begin at a slightly later age than in Men1^tm1.1Ctre heterozygotes

pancreas cyst ( J:67128 )

• acinar cysts in some mice

pancreas necrosis ( J:67128 )

• focal acinar necrosis in some mice

pancreas inflammation ( J:67128 )

• some mice exhibit duct inflammation in the pancreas

homeostasis/metabolism

increased circulating insulin level ( J:67128 )

• in mice with islet hypoplasia and/or pancreatic islet cell tumors

immune system

pancreas inflammation ( J:67128 )

• some mice exhibit duct inflammation in the pancreas

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:67128 )

• some mice exhibit duct inflammation, acinar cysts, focal acinar dysplasia, and focal acinar necrosis unlike wild-type mice

increased stomach tumor incidence ( J:67128 )

• one mouse developed a gastric neuroendocrine tumor

respiratory system

increased lung adenocarcinoma incidence ( J:67128 )

• in 22% of mice

nervous system

increased pituitary adenoma incidence ( J:67128 )

• pituitary adenomas develop in 26% of mice by 16 months of age

• all pituitary tumors secrete prolactin but not ACTH

increased prolactinoma incidence ( J:67128 )

growth/size/body

thyroid gland cyst ( J:67128 )

• thyroid cysts

pancreas cyst ( J:67128 )

• acinar cysts in some mice