Phenotypes Associated with This Genotype

Genotype
MGI:3839574

• Allelic Composition: Tg(Alb-PLG)1Dgi/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:120780 )

• mice infected subcutaneously with the human pathogenic group A streptococcus (GAS) strain UMAA2616 exhibit 75% of mortality unlike similarly treated wild-type mice that exhibit 20% mortality

• mice infected subcutaneously with GAS strain MGAS166 exhibit 35% to 100% of mortality unlike similarly treated wild-type mice that exhibit 30% mortality

• however, mice exhibit normal mortality when infected with GAS strain UMAA2641, which lacks the Ska gene, or when infected intravenously with UMAA2616

• mice infected subcutaneously with PAM-expressing GAS strain AP53 exhibit 80% mortality compared to 20% in similarly treated wild-type mice

immune system

increased susceptibility to bacterial infection ( J:120780 )

• mice infected subcutaneously with the human pathogenic group A streptococcus (GAS) strain UMAA2616 exhibit 75% of mortality unlike similarly treated wild-type mice that exhibit 20% mortality

• mice infected subcutaneously with GAS strain MGAS166 exhibit 35% to 100% of mortality unlike similarly treated wild-type mice that exhibit 30% mortality

• however, mice exhibit normal mortality when infected with GAS strain UMAA2641, which lacks the Ska gene, or when infected intravenously with UMAA2616

• mice infected subcutaneously with PAM-expressing GAS strain AP53 exhibit 80% mortality compared to 20% in similarly treated wild-type mice

• mice infected subcutaneously with GAS exhibit increased bacterial colonies in the spleen compared to similarly infected wild-type mice