Phenotypes Associated with This Genotype

Genotype
MGI:3839457

• Allelic Composition: Tg(Tcrb)93Vbo/0
• Genetic Background: involves: C57BL/6 * C57BL/LiA * CBA/BrA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:66565 )

• 25-33% of peripheral CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b compared to less than 1% of wild-type mice

• 7-10% of CD8⁺ T cells from male mice recognize HY antigen in the context of H-2D^b though the affinity for antigen is 3-fold less

• the reduced percentage and binding affinity is also evident in CD8 single-positive male thymocytes

abnormal T cell clonal deletion ( J:66565 )

• the repertoire of T cell receptors (TCR) on T cells differs between male and female transgenic mice

• male mice have preferential deletion of thymocytes bearing TCR with transgenic beta chains that have high-affinity for HY antigen

• HY specific male T cells represent the low-affinity fraction of the corresponding female T cell population

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells bearing the transgenic TCR-beta chain respond to a 100-fold less HY antigen than transgenic male T cells do

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:66565 )

• 25-33% of peripheral CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b compared to less than 1% of wild-type mice

• 7-10% of CD8⁺ T cells from male mice recognize HY antigen in the context of H-2D^b though the affinity for antigen is 3-fold less

• the reduced percentage and binding affinity is also evident in CD8 single-positive male thymocytes

abnormal T cell clonal deletion ( J:66565 )

• the repertoire of T cell receptors (TCR) on T cells differs between male and female transgenic mice

• male mice have preferential deletion of thymocytes bearing TCR with transgenic beta chains that have high-affinity for HY antigen

• HY specific male T cells represent the low-affinity fraction of the corresponding female T cell population

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells bearing the transgenic TCR-beta chain respond to a 100-fold less HY antigen than transgenic male T cells do