Phenotypes Associated with This Genotype

Genotype
MGI:3839243

• Allelic Composition: Tg(Tcrb)93Vbo/0
• Genetic Background: involves: C57BL/LiA * CBA/BrA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:93247 )

• almost all CD4⁺ and CD8⁺ T cells express the transgenic TCR-beta chain

• cytolytic effector functions of T cells are not affected

abnormal T cell receptor beta chain V(D)J recombination ( J:93247 )

• peripheral T cells have rearranged Dbeta1-Jbeta segments that are not recombined with the Vbeta segments

• this "partial" rearrangement occurs with high frequency and is not observed in wild-type T cells

hematopoietic system

abnormal T cell morphology ( J:93247 )

• almost all CD4⁺ and CD8⁺ T cells express the transgenic TCR-beta chain

• cytolytic effector functions of T cells are not affected

abnormal T cell receptor beta chain V(D)J recombination ( J:93247 )

• peripheral T cells have rearranged Dbeta1-Jbeta segments that are not recombined with the Vbeta segments

• this "partial" rearrangement occurs with high frequency and is not observed in wild-type T cells