Phenotypes Associated with This Genotype

Genotype
MGI:3839124

• Allelic Composition: Tg(SV)427Bri/0
• Genetic Background: C57BL/6J-Tg(SV)427Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79096 , J:147031 )

• mice die by 5 months of age (J:79096)

• mice die at 7 months of age (J:147031)

reproductive system

female infertility ( J:147031 )

♀

reduced male fertility ( J:79096 )

♂ • only 2 of 42 mice are fertile

neoplasm

increased brain tumor incidence ( J:79096 , J:147031 )

• choroid plexus papillomas or carcinomas (J:79096)

• choroids plexus papillomas (J:147031)

cardiovascular system

intracranial hemorrhage ( J:79096 )

• on the cerebral surface

craniofacial

abnormal cranium morphology ( J:79096 )

• mice exhibit a cranium bulge unlike wild-type mice

immune system

enlarged thymus ( J:79096 )

nervous system

intracranial hemorrhage ( J:79096 )

• on the cerebral surface

increased brain tumor incidence ( J:79096 , J:147031 )

• choroid plexus papillomas or carcinomas (J:79096)

• choroids plexus papillomas (J:147031)

skeleton

abnormal cranium morphology ( J:79096 )

• mice exhibit a cranium bulge unlike wild-type mice

hematopoietic system

enlarged thymus ( J:79096 )

endocrine/exocrine glands

enlarged thymus ( J:79096 )