Phenotypes Associated with This Genotype

Genotype
MGI:3839105

• Allelic Composition: Megf8^hlb611/Megf8^hlb611
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Left-right asymmetric defects in Megf8^hlb611/Megf8^hlb611 embryos

cardiovascular system

abnormal cardiac outflow tract development ( J:146805 )

• the outflow tract is shortened compared to in wild-type mice

abnormal direction of heart looping ( J:146805 )

• randomized

transposition of great arteries ( J:146805 , J:311933 )

• 100% of E13.5-E14.5 mutants exhibit transposition of the great arteries (J:311933)

anomalous pulmonary venous connection ( J:146805 )

• mice exhibit abnormal pulmonary venous connections

abnormal heart position or orientation ( J:311933 )

• 67% of E13.5-E14.5 mutants exhibit abnormal cardiac apex; mesocardiac or dextrocardia

dextrocardia ( J:146805 , J:311933 )

• in some mice (J:146805)

mesocardia ( J:146805 , J:311933 )

• in some mice (J:146805)

abnormal heart septum morphology ( J:311933 )

• 100% of E13.5-E14.5 mutants exhibit cardiac septum defects, either ventricular septal defect or atrioventricular septal defect

atrioventricular septal defect ( J:311933 )

ventricular septal defect ( J:311933 )

limbs/digits/tail

preaxial polydactyly ( J:311933 )

• 100% of E13.5-E14.5 mutants exhibit preaxial digit duplication

hematopoietic system

hematopoietic system phenotype ( J:146805 )

N • erythropoiesis is normal

absent spleen ( J:146805 )

• in some mice

accessory spleen ( J:146805 )

• in some mice

embryo

embryo phenotype ( J:146805 )

N • despite heterotaxia, mice exhibit normal nodal cilia rotation

abnormal direction of embryo turning ( J:146805 )

• randomized

digestive/alimentary system

right-sided stomach ( J:146805 )

• right-sided stomach

respiratory system

lung situs inversus ( J:311933 )

• 92% of E13.5-E14.5 mutants exhibit abnormal lung situs

right pulmonary isomerism ( J:146805 )

growth/size/body

heterotaxia ( J:146805 , J:311933 )

• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus (J:311933)

right-sided stomach ( J:146805 )

• right-sided stomach

abdominal situs abnormality ( J:311933 )

• 67% of E13.5-E14.5 mutants exhibit abnormal abdomen situs

lung situs inversus ( J:311933 )

• 92% of E13.5-E14.5 mutants exhibit abnormal lung situs

right pulmonary isomerism ( J:146805 )

situs inversus ( J:311933 )

• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus

immune system

absent spleen ( J:146805 )

• in some mice

accessory spleen ( J:146805 )

• in some mice