Phenotypes Associated with This Genotype

Genotype
MGI:3838991

• Allelic Composition: \Inpp5d^tm1Rkh/\Inpp5d^tm1Rkh; \Rag1^tm1(GFP)Imku/\Rag1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction

immune system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction