Phenotypes Associated with This Genotype

Genotype
MGI:3838395

• Allelic Composition: Ccm2^{Gt(RRG051)Byg}/Ccm2^{Gt(RRG051)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:146528 )

• die before E10

cardiovascular system

abnormal dorsal aorta morphology ( J:146528 )

• the paired dorsal aortas are small or undetectable and completely lack luminal blood at E9

abnormal cardinal vein morphology ( J:146528 )

• when visible the cardinal veins are devoid of luminal blood except at the point where it attaches to the sinus venosus

abnormal vascular endothelial cell development ( J:146528 )

• endothelial cells are present but fail to form lumenized vessels

• in the aorta endothelial junctions are shortened

abnormal vasculogenesis ( J:146528 )

• fail to form lumenized vessels

dilated aortic sac ( J:146528 )

• a dilated aortic sac is seen at E9

hemopericardium ( J:146528 )

• blood cells are frequently detected in the pericardial cavity

pericardial edema ( J:146528 )

• starting at E9

embryo

embryonic growth retardation ( J:146528 )

• starting at E9

homeostasis/metabolism

hemopericardium ( J:146528 )

• blood cells are frequently detected in the pericardial cavity

pericardial edema ( J:146528 )

• starting at E9

growth/size/body

embryonic growth retardation ( J:146528 )

• starting at E9