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Phenotypes Associated with This Genotype
Genotype
MGI:3838391
Allelic
Composition
Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2Gt(OST57859)Lex mutation (0 available); any Fancd2 mutation (53 available)
Usp1tm1.1Ada mutation (0 available); any Usp1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• bone marrow cells have decreased survival after exposure to ionizing radiation compared to controls that are homozygote null for just one allele
• bone marrow cell are also hypersensitive to mitomycin C treatment (MMC) with with increased numbers of chromosome breaks and decreased survival compared to controls that are homozygote null for just one allele

endocrine/exocrine glands
• female mice have severe atrophy of the ovaries

reproductive system
• female mice have severe atrophy of the ovaries

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fanconi anemia complementation group D2 DOID:0111083 OMIM:227646
J:146616


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory