Phenotypes Associated with This Genotype

Genotype
MGI:3838229

• Allelic Composition: Ctla4^tm1Shr/Ctla4^tm1Shr
• Genetic Background: B6.129S4-Ctla4^tm1Shr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell physiology ( J:146644 )

• mutant bone marrow transferred to lymphopenic hosts generates auto-reactive T cells that propagate a multi-organ inflammatory disease

• the same pathological response occurs when chimeric mice are created from Ctla4 null and Rag1 null blastocytes

• mixing of WT, Tcrd null, CD4 null, CD8a null or B7 null bone marrow with Ctla4 null bone marrow prevents autoreactive Ctla4 null T cells from propagating disease

• mixing of Tcrb null or CD28 null bone marrow with Ctla4 null bone marrow fails to prevent disease

abnormal regulatory T cell physiology ( J:146644 )

• wild-type but not Ctla4 null regulatory T cells prevent autoimmune disease when co-transferred with Ctla4 null bone marrow into lymphopenic hosts

autoimmune response ( J:146644 )

• mutant bone marrow transferred to lymphopenic hosts generates auto-reactive T cells that propagate a multi-organ inflammatory disease

• the same pathological response occurs when chimeric mice are created from Ctla4 null and Rag1 null blastocytes

hematopoietic system

abnormal T cell physiology ( J:146644 )

• mutant bone marrow transferred to lymphopenic hosts generates auto-reactive T cells that propagate a multi-organ inflammatory disease

• the same pathological response occurs when chimeric mice are created from Ctla4 null and Rag1 null blastocytes

• mixing of WT, Tcrd null, CD4 null, CD8a null or B7 null bone marrow with Ctla4 null bone marrow prevents autoreactive Ctla4 null T cells from propagating disease

• mixing of Tcrb null or CD28 null bone marrow with Ctla4 null bone marrow fails to prevent disease

abnormal regulatory T cell physiology ( J:146644 )

• wild-type but not Ctla4 null regulatory T cells prevent autoimmune disease when co-transferred with Ctla4 null bone marrow into lymphopenic hosts