Phenotypes Associated with This Genotype

Genotype
MGI:3838225

• Allelic Composition: Cr1l^tm1.1Song/Cr1l^tm1.1Song; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:146538 )

• in the peripheral blood

decreased lymphocyte cell number ( J:146538 )

• mice exhibit T cell lymphopenia

• however, chemical depletion of macrophages ameliorates T cell lymphopenia

decreased CD4-positive, alpha-beta T cell number ( J:146538 )

• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice

• however, thymic CD4+ counts are normal

decreased CD8-positive, alpha-beta T cell number ( J:146538 )

• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice

• however, thymic CD8+ counts are normal

lymph node hypoplasia ( J:146538 )

hematopoietic system

increased B cell number ( J:146538 )

• in the peripheral blood

decreased lymphocyte cell number ( J:146538 )

• mice exhibit T cell lymphopenia

• however, chemical depletion of macrophages ameliorates T cell lymphopenia

decreased CD4-positive, alpha-beta T cell number ( J:146538 )

• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice

• however, thymic CD4+ counts are normal

decreased CD8-positive, alpha-beta T cell number ( J:146538 )

• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice

• however, thymic CD8+ counts are normal