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Phenotypes Associated with This Genotype
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• unlike human patients with familial hypertrophic cardiomyopathy, mice fail to exhibit cardiac hypertrophy
• at 17 months of age
• skinned muscle fibers exhibit increased delta pCa50 values of ATPase and force-pCa relationship compared to in wild-type fibers
• maximal ATPase in skinned muscle fibers is reduced 22% compared to in wild-type cells
• maximal force in skinned muscle fibers is reduced 32% compared to in wild-type cells
• papillary muscle fibers exhibit slower myosin cross-bridge dissociation and normalized force compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 10; CMH10 608758 J:146091

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory