About   Help   FAQ
Phenotypes Associated with This Genotype
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• unlike human patients with familial hypertrophic cardiomyopathy, mice fail to exhibit cardiac hypertrophy
• at 17 months of age
• skinned muscle fibers exhibit increased delta pCa50 values of ATPase and force-pCa relationship compared to in wild-type fibers
• maximal ATPase in skinned muscle fibers is reduced 22% compared to in wild-type cells
• maximal force in skinned muscle fibers is reduced 32% compared to in wild-type cells
• papillary muscle fibers exhibit slower myosin cross-bridge dissociation and normalized force compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 10; CMH10 608758 J:146091

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory