Phenotypes Associated with This Genotype

Genotype
MGI:3838021

• Allelic Composition: Caly^tm1.1Cber/Caly^tm1.1Cber
• Genetic Background: C57BL/6-Caly^tm1.1Cber

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle recycling ( J:146583 , J:145984 )

• cultured neurons have defects in clathrin-mediated endocytosis (CME) (J:146583)

• 60 minutes after induction of CME, mutant neurons have two-fold less uptake of tranferrin receptor from the cell surface than controls (J:146583)

• neurons exhibit alterations in stimulated removal of cell surface AMPARs (J:145984)

• GluR1 and GluR2 removal from the cell surface after stimulation with N-methyl-D-aspartate (NMDA) is significantly slower with only 10% removed after 15 minutes of incumbation compared to 50% in wild-type (J:145984)

absent long-term depression ( J:145984 )

• treatment of hippocampal neuron cultures with NMDA does not produce a prolonged depression in mEPSC amplitude as it does in wild-type neurons

• using hippocampal CA1 slices, the 58 2% decrease in excitatory post synaptic current detected in WT slices after low frequency stimulation does not occur in mutant CA1 slices