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Phenotypes Associated with This Genotype
Genotype
MGI:3837853
Allelic
Composition
Axltm1Grl/Axltm1Grl
Mertktm1Grl/Mertktm1Grl
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axltm1Grl mutation (2 available); any Axl mutation (58 available)
Mertktm1Grl mutation (2 available); any Mertk mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

reproductive system
• 4% of females exhibit vaginal atresia
• double mutant Sertoli cells show a ~35% decrease in phagocytosis of apoptotic spermatogenic cells relative to wild-type controls, as determined by lipid droplet formation using Oil Red O staining; this reduction is similar to that observed in Mertktm1Grl singly mutant Sertoli cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory