About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3837392
Allelic
Composition		 Mcl1tm1Yen/Mcl1tm1Yen
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Yen mutation (0 available); any Mcl1 mutation (35 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-positive T cell morphology ( J:146246 )
• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR
decreased CD4-positive, alpha-beta T cell number ( J:146246 )
• mice have decreased frequency and numbers of transgenic CD4+ T cells in the thymus and in the periphery

hematopoietic system
abnormal double-positive T cell morphology ( J:146246 )
• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR
decreased CD4-positive, alpha-beta T cell number ( J:146246 )
• mice have decreased frequency and numbers of transgenic CD4+ T cells in the thymus and in the periphery

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory