Phenotypes Associated with This Genotype

Genotype
MGI:3837392

• Allelic Composition: Mcl1^tm1Yen/Mcl1^tm1Yen; Tg(TcraTcrb)425Cbn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD4-positive, alpha-beta T cell number ( J:146246 )

• mice have decreased frequency and numbers of transgenic CD4⁺ T cells in the thymus and in the periphery

hematopoietic system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD4-positive, alpha-beta T cell number ( J:146246 )

• mice have decreased frequency and numbers of transgenic CD4⁺ T cells in the thymus and in the periphery