Phenotypes Associated with This Genotype

Genotype
MGI:3837369

• Allelic Composition: Tg(AZIP/F)1Vsn/0
• Genetic Background: FVB-Tg(AZIP/F)1Vsn/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:145998 )

• insulin content in the pancreata is increased compared to in wild-type mice

decreased circulating glucose level ( J:145998 )

increased circulating insulin level ( J:145998 )

• at birth and 2 weeks of age, mice exhibit increased serum insulin levels compared to in wild-type mice

• however, mice treated with isoproterenol exhibit lowered serum levels of insulin

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:145998 )

• beta-cell proliferation is increased compared to in wild-type mice

increased pancreatic beta cell mass ( J:145998 )

• beta-cell proliferation, mass and area are increased compared to in wild-type mice

increased insulin secretion ( J:145998 )

• insulin content in the pancreata is increased compared to in wild-type mice

growth/size/body

decreased body mass index ( J:145998 )

• at 2 weeks of age

decreased body weight ( J:145998 )

• at 2 weeks of age

cellular

increased pancreatic beta cell proliferation ( J:145998 )

• beta-cell proliferation is increased compared to in wild-type mice