Phenotypes Associated with This Genotype

Genotype
MGI:3837364

• Allelic Composition: Del(3Bglap2-Bglap)2Kry/Del(3Bglap2-Bglap)2Kry
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone diaphysis morphology ( J:34440 )

• increase in the width of the diaphysis is observed at 9 months of age

abnormal bone structure ( J:34440 )

• long bones of ovariectomized mutants show a greater decrease in bone density, yield energy, failure load and stiffness than wild-type bones, indicating bone fragility similar to osteoporosis after ovariectomy

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface

increased compact bone thickness ( J:34440 )

• width of cortical bone is increased at 6 months of age, reaching 150% of the wild-type width by 9 months of age

increased trabecular bone thickness ( J:34440 )

• mutants contain more cancellous bone than wild-type mice at 6 and 9 months of age

increased bone mass ( J:34440 )

abnormal skeleton development ( J:34440 )

• cancellous and cortical bone formation rates are increased in long bones and vertebrae

abnormal bone remodeling ( J:34440 )

• develop bone remodeling abnormalities by 6 months of age

increased bone strength ( J:34440 )

• 6 month old mice show a significant increase in failure load, indicating increased bone strength

hematopoietic system

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface

immune system

increased osteoclast cell number ( J:34440 )

• increase in osteoclast number and surface