Phenotypes Associated with This Genotype

Genotype
MGI:3837309

• Allelic Composition: Il6st^tm1Ern/Il6st^tm1Ern; Stat3^tm1Aki/Stat3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:100160 )

N • improved survival

immune system

immune system phenotype ( J:100160 , J:139226 , J:142883 )

N • splenomegaly fails to develop (J:100160)

N • neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal (J:139226)

N • response to arthritis induced with methylated serum albumin is comparable to control animals (J:142883)

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• compared with LPS-treated Il6st^tm1Ern homozygotes

digestive/alimentary system

digestive/alimentary phenotype ( J:100160 )

N • stomach size remains normal

neoplasm

neoplasm ( J:100160 )

N • numbers of gastric adenomas is reduced

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes