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Phenotypes Associated with This Genotype
Genotype
MGI:3837205
Allelic
Composition		 Il6sttm1Ern/Il6sttm1Wme
Tg(Alb1-cre)7Gsc/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Ern mutation (17 available); any Il6st mutation (84 available)
Il6sttm1Wme mutation (2 available); any Il6st mutation (84 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:97327 )
N
• do not suffer liver damage from ConA treatment if pretreated with Il6
abnormal liver regeneration ( J:135290 )
• maximal DNA synthesis in hepatocytes after partial hepatectomy occurs after about 48 hours
• hepatocyte growth factor has no effect on hepatocyte proliferation unless administered with Il6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory