Phenotypes Associated with This Genotype

Genotype
MGI:3837138

• Allelic Composition: Lmna^tm4Lgf/Lmna⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rib fractures in Lmna^tm4Lgf/Lmna⁺ and Lmna^tm1Lgf/Lmna⁺ mice

mortality/aging

premature death ( J:146099 )

• mice die between 35 and 45 weeks

cellular

abnormal cell nucleus morphology ( J:146099 )

• mouse embryonic fibroblasts exhibit misshapen nuclei unlike wild-type cells

growth/size/body

decreased body weight ( J:146099 )

skeleton

rib fractures ( J:146099 )

• mice exhibit more rib fractures than in wild-type mice but less than in Lmna^tm1Lgf heterozygotes