Phenotypes Associated with This Genotype

Genotype
MGI:3837130

• Allelic Composition: Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:145530 )

N • striatal volume is similar in both transgenic and wild-type at either 6 or 12 months of age

abnormal medium spiny neuron morphology ( J:145530 )

• nuclei of medium spiny stellate neurons in both 6 and 12 month old transgenics are smaller and darker than wild-type

decreased neuron number ( J:145530 )

• numbers of neurons are reduced in striatum of 12, but not 6, month old transgenics

neuron degeneration ( J:145530 )

• numbers of neurons are reduced in striatum of 12, but not 6, month old transgenics

• reduced neuron density is observed in striatum of 12, but not 6, month old transgenics

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:186924 )

N • mutants exhibit normal body weight, blood glucose, plasma insulin levels, nonfasting blood glucose and nonfasting plasma insulin, and normal glucose and insulin tolerance, indicating normal glucose homeostasis and insulin sensitivity

amyloidosis ( J:186924 )

• increase in circulating amyloid beta protein levels