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Phenotypes Associated with This Genotype
Genotype
MGI:3837032
Allelic
Composition
Il6sttm1Ern/Il6sttm1Ern
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Ern mutation (12 available); any Il6st mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• age dependent enlargement of the proximal small intestine starting around 6-8 weeks of age
• hyperproliferative lesions in the antropyloric mucosa (J:79073)
• gastric outlet obstruction (J:79073)
• fewer mucus producing cells (J:79073)
• enlarged glandular structure with increased branching (J:79073)
• infiltrating lymphocytes abundant in the lamina propria and intraepithelial compartments (J:79073)
• non adenomatous stomach is hyperplastic with more pronounced rugae (J:87206)
• total area is increased from 16 weeks of age onward (J:87206)
• age dependent enlargement starting around 6-8 weeks of age
• completely resistant to 3.5% dextran sodium sulfate
• in mice over 20 weeks of age
• gastritis is seen in all adults
• mixed mononuclear cells and polymorphonuclear leukocytes involved

immune system
• age dependent enlargement starting around 6-8 weeks of age
• neutrophil infiltration of the peritoneal cavity peaks more rapidly in induced inflammation than in controls (6 vs 12 hrs)
• neutrophils cleared more rapidly than in controls in induced inflammation
• completely resistant to 3.5% dextran sodium sulfate
• gastritis is seen in all adults
• mixed mononuclear cells and polymorphonuclear leukocytes involved
• increased overall severity of arthritis induced with methylated bovine serum albumin

homeostasis/metabolism
• completely resistant to 3.5% dextran sodium sulfate

neoplasm
• presence of pseudopolyploid diffuse adenomatous lesions in the stomach (J:79073)
• become larger and more numerous with age (J:87206)
• involve dysplastic cells and branching tortuous gastric glands (J:87206)

skeleton
• increased overall severity of arthritis induced with methylated bovine serum albumin
• on trabecular bone surfaces
• trabecular numbers reduced, particularly in males
• trabecular thickness reduced, particularly in males

hematopoietic system
• age dependent enlargement starting around 6-8 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
stomach cancer DOID:10534 OMIM:137215
OMIM:613659
J:87206


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory