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Phenotypes Associated with This Genotype
Genotype
MGI:3836922
Allelic
Composition
Cd4tm1Mak/Cd4tm1Mak
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic
Background
B6.Cg-Cd4tm1Mak Igh-Jtm2(3H9-VDJ*)Mwg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Mak mutation (5 available); any Cd4 mutation (71 available)
Igh-Jtm2(3H9-VDJ*)Mwg mutation (3 available); any Igh-J mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• anti-dsDNA antibodies of IgG2a isotype are detected in the sera of mice at levels slightly less than that of 56R mice that have CD4 T cells present
• anti-dsDNA antibodies with IgM, IgG2b, IgG3 are also present in mice at 6 months of age though at levels less than those found in 56R mice with CD4 T cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory