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Phenotypes Associated with This Genotype
Genotype
MGI:3836813
Allelic
Composition
Spred1tm1Hiin/Spred1tm1Hiin
Genetic
Background
B6.Cg-Spred1tm1Hiin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred1tm1Hiin mutation (1 available); any Spred1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite abnormal CNS transmission, mice exhibit normal dendritic arborization
• the slope of field excitatory postsynaptic potentials is decreased compared to in wild-type mice
• following a single theta burst stimulation
• following a train of low-frequency stimulation
• at 10 and 20 ms interpulse intervals

behavior/neurological
• in a T-maze, mice exhibit reduced visual discrimination compared to wild-type mice
• in a hidden-platform Morris water maze assay, mice perform worse than wild-type mice in the second week
• however, motivation and sensory-motor abilities are normal
• mice spend less time in the target quadrant than wild-type mice in a Morris water maze when the platform is removed
• mice swim slower and float more than wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Legius Syndrome 611431 J:144031


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory