Phenotypes Associated with This Genotype

Genotype
MGI:3836813

• Allelic Composition: Spred1^tm1Hiin/Spred1^tm1Hiin
• Genetic Background: B6.Cg-Spred1^tm1Hiin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:144031 )

N • despite abnormal CNS transmission, mice exhibit normal dendritic arborization

abnormal excitatory postsynaptic potential ( J:144031 )

• the slope of field excitatory postsynaptic potentials is decreased compared to in wild-type mice

reduced long-term potentiation ( J:144031 )

• following a single theta burst stimulation

absent long-term depression ( J:144031 )

• following a train of low-frequency stimulation

enhanced paired-pulse facilitation ( J:144031 )

• at 10 and 20 ms interpulse intervals

behavior/neurological

abnormal discrimination learning ( J:144031 )

• in a T-maze, mice exhibit reduced visual discrimination compared to wild-type mice

abnormal spatial learning ( J:144031 )

• in a hidden-platform Morris water maze assay, mice perform worse than wild-type mice in the second week

• however, motivation and sensory-motor abilities are normal

abnormal spatial working memory ( J:144031 )

• mice spend less time in the target quadrant than wild-type mice in a Morris water maze when the platform is removed

increased thigmotaxis ( J:144031 )

impaired swimming ( J:144031 )

• mice swim slower and float more than wild-type mice