Mouse Genome Informatics
hm
    Spred1tm1Hiin/Spred1tm1Hiin
B6.Cg-Spred1tm1Hiin
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• despite abnormal CNS transmission, mice exhibit normal dendritic arborization (J:144031)
• the slope of field excitatory postsynaptic potentials is decreased compared to in wild-type mice
• following a single theta burst stimulation
• following a train of low-frequency stimulation
• at 10 and 20 ms interpulse intervals

behavior/neurological
• in a T-maze, mice exhibit reduced visual discrimination compared to wild-type mice
• in a hidden-platform Morris water maze assay, mice perform worse than wild-type mice in the second week
• however, motivation and sensory-motor abilities are normal
• mice spend less time in the target quadrant than wild-type mice in a Morris water maze when the platform is removed
• mice swim slower and float more than wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Legius Syndrome 611431 J:144031