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Phenotypes Associated with This Genotype
Genotype
MGI:3836742
Allelic
Composition		 \Sh2d1b1tm2Vei/\Sh2d1b1tm2Vei
\Sh2d1b2tm1Vei/\Sh2d1b2tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1tm2Vei mutation (0 available); any Sh2d1b1 mutation (9 available)
Sh2d1b2tm1Vei mutation (0 available); any Sh2d1b2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell are inhibited from killing B16 melonama cells expressing CRACC

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells lack enhanced lysis of target cells expressing Slamf7 (CRACC)
• NK cell are inhibited from killing B16 melonama cells expressing CRACC

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory