Phenotypes Associated with This Genotype

Genotype
MGI:3836737

• Allelic Composition: Csf3r^{tm4(Epor)Link}/Csf3r^{tm4(Epor)Link}
• Genetic Background: B6.129X1-Csf3r^{tm4(Epor)Link}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls

increased bone marrow cell number ( J:79567 )

• elevated bone marrow neutrophiles after treatment with granulocyte-colony stimulating factor (G-CSF)

decreased neutrophil cell number ( J:79567 )

• very few neutrophiles in the circulation after treatment with G-CSF

immune system

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls

decreased neutrophil cell number ( J:79567 )

• very few neutrophiles in the circulation after treatment with G-CSF

cellular

impaired neutrophil chemotaxis ( J:79567 )

• defect in mobilization from bone marrow to blood

• no mobilization in response to G-CSF

• mobilization in response to Il8 is increased but less than in controls