Phenotypes Associated with This Genotype

Genotype
MGI:3836733

• Allelic Composition: Csf3r^{tm4(Epor)Link}/Csf3r^{tm4(Epor)Link}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced

abnormal common myeloid progenitor cell morphology ( J:79825 )

• bone marrow cells respond similarly to controls when treated with G-CSF

• colonies formed are smaller than with controls

• erythropoiesis and erythroid progenitors are unaffected

decreased granulocyte number ( J:79825 )

• numbers of mature granulocytes reduced to about 70% of controls

decreased neutrophil cell number ( J:79825 )

• number of circulating neutrophils about 15% of controls

• circulating neutrophiles show very little increase after treatment with granulocyte-colony stimulating factor (G-CSF)

immune system

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced

decreased granulocyte number ( J:79825 )

• numbers of mature granulocytes reduced to about 70% of controls

decreased neutrophil cell number ( J:79825 )

• number of circulating neutrophils about 15% of controls

• circulating neutrophiles show very little increase after treatment with granulocyte-colony stimulating factor (G-CSF)

cellular

impaired neutrophil chemotaxis ( J:79825 )

• chemotaxis response to Il8 is significantly reduced