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Phenotypes Associated with This Genotype
Genotype
MGI:3836583
Allelic
Composition		 Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/?
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (69 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
Tg(Myh6-NFATC4)#Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:84138 )
• viability extended to around E12
• no live embryos at E12.5 or later

cardiovascular system
cardiovascular system phenotype ( J:84138 )
N
• normal heart phenotype at E11.5
• heart mitochondrial respiration normal at E10.5
• 70% of mitochondria are normal in heart muscle at E10.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory