Phenotypes Associated with This Genotype

Genotype
MGI:3836581

• Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm; Nfatc4^tm1Jmk/Nfatc4^tm1Jmk
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84138 )

• embryos either necrotic or resorbed at E11.5

• no live embryos after E11.5

cardiovascular system

abnormal heart morphology ( J:84138 )

• thin and translucent at E10.5

• pericardial effusions

abnormal myocardium layer morphology ( J:84138 )

• more than 50% reduction in proliferation at E10.5

• no apoptosis

abnormal myocardial fiber mitochondrial morphology ( J:84138 )

• restricted to mitochondria in the heart

• ventricular myocardium with enlarged and disorganized mitochondria

• defects in cristae formation, fewer in number or absent

• ventricular mitochondria with dilated tubules or onion-like swirls

abnormal myocardium compact layer morphology ( J:84138 )

• more than 50% reduction in the number of cells

abnormal heart development ( J:84138 )

• defects in cardiac development at E10.5

abnormal heart ventricle morphology ( J:84138 )

• ventricular myocardium with enlarged and disorganized mitochondria

• defects in cristae formation, fewer in number or absent

• ventricular mitochondria with dilated tubules or onion-like swirls

abnormal trabecula carnea morphology ( J:84138 )

• thinner

• fewer in number

dilated heart ( J:84138 )

• at E10.5

abnormal cardiovascular system physiology ( J:84138 )

• 30% reduction in mitochondrial respiration

cellular

abnormal myocardial fiber mitochondrial morphology ( J:84138 )

• restricted to mitochondria in the heart

• ventricular myocardium with enlarged and disorganized mitochondria

• defects in cristae formation, fewer in number or absent

• ventricular mitochondria with dilated tubules or onion-like swirls

abnormal cellular respiration ( J:84138 )

• 30% reduction in mitochondrial respiration

hematopoietic system

anemia ( J:84138 )

• at E10.5

embryo

embryonic growth retardation ( J:84138 )

• mild generalized developmental delay at E10.5

• head, tail and limb buds normal at E10.5

growth/size/body

embryonic growth retardation ( J:84138 )

• mild generalized developmental delay at E10.5

• head, tail and limb buds normal at E10.5

muscle

abnormal myocardium layer morphology ( J:84138 )

• more than 50% reduction in proliferation at E10.5

• no apoptosis

abnormal myocardial fiber mitochondrial morphology ( J:84138 )

• restricted to mitochondria in the heart

• ventricular myocardium with enlarged and disorganized mitochondria

• defects in cristae formation, fewer in number or absent

• ventricular mitochondria with dilated tubules or onion-like swirls

abnormal trabecula carnea morphology ( J:84138 )

• thinner

• fewer in number

abnormal myocardium compact layer morphology ( J:84138 )

• more than 50% reduction in the number of cells