Phenotypes Associated with This Genotype

Genotype
MGI:3836577

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

prostate gland hyperplasia ( J:143034 )

♂ • at 200 days, 100% of mice exhibit atypical hyperplasia unlike wild-type mice

♂ • at 500 days, 93% of mice exhibit atypical hyperplasia unlike wild-type mice

increased prostate gland adenocarcinoma incidence ( J:143034 )

♂ • in 7% of mice at 500 days

increased prostate intraepithelial neoplasia incidence ( J:143034 )

♂ • at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice

♂ • at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:143034 )

♂ • in 7% of mice at 500 days

increased prostate intraepithelial neoplasia incidence ( J:143034 )

♂ • at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice

♂ • at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice

endocrine/exocrine glands

prostate gland hyperplasia ( J:143034 )

♂ • at 200 days, 100% of mice exhibit atypical hyperplasia unlike wild-type mice

♂ • at 500 days, 93% of mice exhibit atypical hyperplasia unlike wild-type mice

increased prostate gland adenocarcinoma incidence ( J:143034 )

♂ • in 7% of mice at 500 days

increased prostate intraepithelial neoplasia incidence ( J:143034 )

♂ • at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice

♂ • at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:143034