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Phenotypes Associated with This Genotype
Genotype
MGI:3836562
Allelic
Composition		 Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation (1 available); any Btk mutation (20 available)
Tg(IGH-Btk)1Witt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory