About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3836561
Allelic
Composition		 Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (76 available)
Btktm1Wk mutation (1 available); any Btk mutation (20 available)
Tg(IGH-Btk)1Witt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory