Phenotypes for Blnk MGI:3836560 MGI Mouse

abnormal B cell differentiation ( J:58805 )

• splenic B cells are larger in size and express higher membrane IgM levels indicating a defect in maturation to the B220^hiIgM^loIgD^hi stage

increased pro-B cell number ( J:58805 )

• accumulate B220+CD43+ pro-B cells

arrested B cell differentiation ( J:58805 )

• profound block in B cell development

• cells fail to progress efficiently from the immature stage to the transitional stage

decreased mature B cell number ( J:58805 )

• decrease in IgM+ peripheral B cells in the spleen and a marked reduction in B220^hiIgM+ and IgM^loIgD^hi B cells in the bone marrow and periphery, respectively

• older mice have increased numbers of B220+ IgM+ B cells compared to younger mice but the numbers are still more than 10 times lower than in age matched controls

abnormal mature B cell morphology ( J:58805 )

• the few IgM+ peripheral B cells that are present are larger in size compared to controls

absent B-1b cells ( J:58805 )

• absent from the spleen and peritoneum

decreased B-1a cell number ( J:58805 )

decreased splenocyte number ( J:58805 )

• a 65% reduction in splenocyte numbers

decreased immunoglobulin level ( J:58805 )

cardiovascular system phenotype ( J:58805 )

N	• despite the occurrence of hemorrhages in mice null for related proteins, no signs of gross hemorrhage are seen in these mice