Phenotypes Associated with This Genotype

Genotype
MGI:3836475

• Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh}; Ercc3^tm2Jhjh/Ercc3^tm2Jhjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145759 )

• mice die within 2 days of birth

cellular

increased cellular sensitivity to gamma-irradiation induced cell death ( J:145759 )

increased cellular sensitivity to ultraviolet irradiation induced cell death ( J:145759 )

• mouse embryonic fibroblasts exhibit slightly increased UV sensitivity compared to cells homozygous for either allele

increased cellular sensitivity to oxidative stress ( J:145759 )

• mouse embryonic fibroblasts exhibit increased sensitivity to oxidative stress induced by paraquat treatment compared to similarly treated wild-type cells

growth/size/body

postnatal growth retardation ( J:145759 )

• mice fail to grow after birth despite nursing normally

homeostasis/metabolism

increased cellular sensitivity to gamma-irradiation induced cell death ( J:145759 )

increased cellular sensitivity to oxidative stress ( J:145759 )

• mouse embryonic fibroblasts exhibit increased sensitivity to oxidative stress induced by paraquat treatment compared to similarly treated wild-type cells