Analysis Tools
mortality/aging
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• most severely affected mice die between 3 and 4 weeks of age
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• some mice exhibit symptoms of premature aging including progressive cachexia, early cessation of growth, neurological abnormalities, and severely reduced life span
• however, mice do not exhibit osteoporosis or increased incidence of spontaneous tumors
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reproductive system
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• prematurely at 1.5 years of age
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behavior/neurological
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• in the last week of live for mice that die prematurely
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• at 2 months of age, impaired hindlimb coordination is occasional observed in 30% of mice unlike in wild-type mice
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• mild gait abnormalities are observed in mice from P12 to 2 months of age and again in ageing mice that develop pronounced kyphosis
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• 5 of 23 mice exhibit abnormal hyperactivity, excitability and nervous behavior but only 1 mouse continued to display these behaviors beyond 2 months of age
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cellular
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• mouse embryonic fibroblasts exhibit increased sensitivity to oxidative stress induced by paraquat treatment compared to similarly treated wild-type cells
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growth/size/body
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• some mice exhibit reduced weight between P10 and P21 compared to wild-type mice
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• after P10 mice fail to gain weight
• however, mice surviving after 3 months reach normal weight
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skeleton
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• at 1.5 years of age, mice exhibit deformed and thickened skulls, mainly in the occipital region, compared to wild-type mice
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• severe in the last week of live for mice that die prematurely
• between 8 and 12 months, 5 of 23 mice exhibit premature kyphosis
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muscle
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• occasional in 30% of mice at 2 months of age
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craniofacial
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• at 1.5 years of age, mice exhibit deformed and thickened skulls, mainly in the occipital region, compared to wild-type mice
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endocrine/exocrine glands
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• prematurely at 1.5 years of age
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