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Phenotypes Associated with This Genotype
Genotype
MGI:3836169
Allelic
Composition
Rhotm1Phm/Rhotm1Phm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1Phm mutation (2 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 48 days, the retinal outer segment and retinal inner segment are thinned further than at earlier time points unlike in wild-type mice
• the retinal outer segment is thinner than in wild-type or heterozygous mice
• at 28 days, the outer nuclear layer (ONL) is 8 to 10 nuclei thick compared to 10 to 12 nucleic in wild-type mice
• at 48 days, the ONL is reduced to half of the width at 24 days
• degeneration is complete by 3 months
• light-adapted mice exhibit a somewhat reduced cone response without an a-wave unlike in wild-type mice
• dark-adapted mice exhibit no electroretinography responses below -0.3 cd/m2 and while small b-waves are generated at high intensities no a-wave is observed
• b-wave response is narrower with a faster time course than in wild-type mice and lacks most of the oscillatory potential observed on the leading edge of the dark-adapted b-waves in wild-type mice

nervous system
• at 48 days, the retinal outer segment and retinal inner segment are thinned further than at earlier time points unlike in wild-type mice
• the retinal outer segment is thinner than in wild-type or heterozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:38098


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory