Phenotypes Associated with This Genotype

Genotype
MGI:3836053

• Allelic Composition: Brca1^tm2Cxd/Brca1⁺; Tg(KRT5-E2F1)2Dgj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:85354 )

• mutants develop tumors after 1 year of age and by 70 weeks, 50% of mutants have tumors

increased skin tumor incidence ( J:85354 )

• majority of tumors occur in the skin

increased squamous cell carcinoma incidence ( J:85354 )

• majority of tumors are squamous cell carcinoma

integument

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation

abnormal epidermal layer morphology ( J:85354 )

• mutants exhibit increased epidermal proliferation and apoptosis

increased skin tumor incidence ( J:85354 )

• majority of tumors occur in the skin

cellular

increased keratinocyte proliferation ( J:85354 )

• increase in basal keratinocyte proliferation